According to a study published in the Journal of the American Medical Association, magnesium supplements can slow the progression of age-related liver disease, such as cirrhosis and hepatocellular carcinoma. In the study, researchers at the University of California, San Francisco (UCSF) School of Medicine studied the effects of magnesium supplementation on the development of HCC, a type of liver cancer, in mice.
The researchers found that mice fed a high-methionine diet, which is high in magnesium, had a significantly lower risk of developing the disease compared to mice on a normal diet.
In addition, the mice that were supplemented with magnesium had lower levels of a protein known as MMP-9, an enzyme that is known to play a role in liver cell growth and development, and a higher level of an antioxidant called superoxide dismutase (SOD), which protects the liver from damage caused by free radicals.
These findings suggest that magnesium may be an effective treatment for the prevention and treatment of cancer and other liver diseases, said study co-author and UCSF professor of medicine and of biochemistry and biophysics, Dr. Michael J. Siegel, MD, PhD.
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Can magnesium affect liver?
The status of magnesium is related to the function of the liver. magnesium deficiency is a major cause of liver disease, and it has a significant effect on body magnesium content. Magnesium deficiency has been associated with an increased risk of cirrhosis of the liver and liver cancer, as well as with a reduced life expectancy.
In the United States, the Dietary Guidelines for Americans (DGAs) recommend a daily intake of 2,300 mg of magnesium for men and 1,500 mg for women. The Dietary Reference Intakes (DRIs) for magnesium are based on the Recommended Dietary Allowance (RDA) of 1.2 mg/day for adults and 0.8 mg per kg of body weight for children and adolescents (1).
Is magnesium hard on the liver or kidneys?
Patients with chronic kidneys disease can accumulate excessive amounts of magnesium in their blood. Muscle weakness, muscle cramps, dizziness, nausea, vomiting, and other symptoms can be caused by magnesium in the blood. In addition, magnesium supplements may increase the risk of heart attack and stroke in patients with high blood pressure, heart disease, diabetes, or high cholesterol. Patients with these conditions should be advised to limit their magnesium intake.
What supplements are hard on your liver?
According to a new study published in the Journal of the American Medical Association (JAMA), green tea extract, steroids, and multi-ingredient supplements are some of the top products that can cause liver injury.
The study, conducted by researchers at the University of California, San Francisco (UCSF) School of Medicine and published online in JAMA Internal Medicine, looked at more than 1,000 patients with chronic liver disease and found that the use of these products was associated with an increased risk of liver cirrhosis and liver cancer, as well as increased rates of hepatitis C and hepatitis B. The study was funded by the National Institutes of Health (NIH), the U.S. Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC) and was conducted in collaboration with the UCSF Hepatology Research Center and other research centers.
“This is the first study to examine the association between the consumption of dietary supplements and hepatocellular carcinoma (HCC) in a large population-based cohort of patients,” said lead author Dr. Michael J. Siegel, associate professor of medicine and of epidemiology and biostatistics.
Does magnesium cause fatty liver?
Magnesium Intake Is Inversely Associated with the Risk of Non-Alcoholic Fatty Liver Disease: A Prospective Cohort Study.
J. A. M. van der Meer, J. Janssen, M.-A. de Vries, A.-M. Van der Schouw, H. C. Verhulst, S. W. Buitelaar, E. L. Rietveldt, P. G. Veenendaal, R. D. Eijkemans and J.-P. Geurts, Dietary magnesium intake and the risk of non-alcoholic fatty liver disease: a systematic review and meta-analysis, Clinical Gastroenterology and Hepatocellular Carcinoma, 12, 3,, the European Society of Clinical Nutrition and Metabolism (ESCN), the American Society for Nutritional Sciences (ASNS) and The European Association of Dietetic Consultants (EADC).
The authors declare no conflict of interest.
Is 800mg of magnesium too much?
It is safe for most adults to have a daily dose of less than 350. Magnesium can cause stomach upset, nausea, vomiting, and other side effects in some people. It can lead to serious health problems, such as heart disease, high blood pressure, stroke, and heart attack, when taken in large amounts.
Magnesium supplements are not recommended for pregnant women, nursing mothers, children under 6 years of age, people with diabetes, those with high cholesterol or triglycerides, women who are pregnant or planning to become pregnant, men who have sex with men (MSM), or anyone who is taking any prescription or over-the-counter medications. Talk to your doctor before taking magnesium supplements if you have any of these conditions.
Can you have too much magnesium in your system?
Magnesium is important for well-being, but too much can cause problems, such as indigestion, lethargy, and an irregular heartbeat. In rare cases, a magnesium overdose can be fatal. Magnesium toxicity is rare in healthy people, and the levels of the mineral in the blood are usually normal.
The most common signs of toxicity are nausea, vomiting, diarrhea, muscle cramps, headache, dizziness, weakness, anxiety, irritability, depression, fatigue, loss of appetite, constipation, nausea and vomiting. The symptoms can last from a few hours to several days. If you experience any of these symptoms, call your doctor or poison control center right away.
